Jan 17

The Network of “BioThings”

Headshot of Chunlei Wu, Ph.D.

By Chunlei Wu, Ph.D. Associate Professor at Scripps Research Department of Integrative Structural and Computational Biology Biomedical knowledge is typically centered around the variety of biological entity types, such as genes, genetic variants, drugs, diseases, etc. Collectively, we refer to them as “BioThings.” The volume of biomedical data has grown explosively, thanks to the efforts …

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Permanent link to this article: https://ncip.nci.nih.gov/blog/the-network-of-biothings/

Dec 19

Towards FAIR&R Cancer Data Analysis

By Saurabh Sinha, Ph.D., Liz Williams, and Ishwar Chandramouliswaran         In an era of unprecedented growth in the size and variety of datasets and the number of software tools, there is an ever-increasing need for frameworks that connect and integrate data and tools within a secure and easy-to-use research ecosystem. In the …

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Permanent link to this article: https://ncip.nci.nih.gov/blog/towards-fairr-cancer-data-analysis/

Dec 11

Announcing the Release of the Imaging Data Commons Request for Proposals

Dr. Stephen Jett Headshot

 By Stephen D. Jett, Ph.D. AAAS Science & Technology Policy Fellow Center for Biomedical Informatics and Information Technology National Cancer Institute In 2016, the Cancer MoonshotSM was announced with the intent to accelerate progress in cancer research and speed the transition from laboratory discovery to therapeutics. A Blue Ribbon Panel was established, which made twelve recommendations …

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Permanent link to this article: https://ncip.nci.nih.gov/blog/announcing-release-imaging-data-commons-request-proposals/

Nov 08

Shape the Data Sharing Landscape: Make a Difference

Vivian Ota Wang, Deputy Director of NCI's Office of Data Sharing

By: Vivian Ota Wang, Ph.D. Deputy Director, Office of Data Sharing Center for Biomedical Informatics and Information Technology National Cancer Institute Broad and equitable data sharing can be interpreted many ways. For NCI’s Office of Data Sharing, this means balancing the support of exciting science and innovation and the needs of research and participant communities …

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Permanent link to this article: https://ncip.nci.nih.gov/blog/shape-data-sharing-landscape-make-difference/

Sep 25

NCI’s Office of Data Sharing: Setting a “Gold” Standard for Childhood Cancer

Jaime M. Guidry Auvil headshot (A woman with shoulder length brown hair in a gray suit jacket with a white collar) on a white and blue background

By Jaime M. Guidry Auvil, Ph.D. Director, Office of Data Sharing Center for Biomedical Informatics and Information Technology Dr. Jaime M. Guidry Auvil serves as the director of the newly-launched NCI Office of Data Sharing (ODS). Headquartered at the Center for Biomedical Informatics and Information Technology, ODS is creating a comprehensive data sharing vision and …

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Permanent link to this article: https://ncip.nci.nih.gov/blog/ncis-office-data-sharing-setting-gold-standard-childhood-cancer/

Sep 20

The Promise and the Challenge of Deep Learning in Pathology

Lee Cooper's headshot: A man standing in front of trees with a white shirt and black suit jacket on a blue and white background.

By Lee Cooper, Ph.D. Assistant Professor, Department of Biomedical Informatics Emory University School of Medicine Assistant Professor, Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University One of the most exciting developments of the past decade has been the success of methods broadly described as deep learning. While the roots …

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Permanent link to this article: https://ncip.nci.nih.gov/blog/promise-challenge-deep-learning-pathology/

Aug 08

Predictive Modeling for Pre-clinical Drug Screening: Improving Models Derived From Observational Studies Using Machine Learning and Simulation

Authors: Jim Doroshow, M.D., Yvonne A. Evrard, Ph.D., and Rick Stevens

This blog post, the fifth, concludes our series that discusses the principles underlying the collaborative project “Joint Design of Advanced Computing Solutions for Cancer (JDACS4C).” Investigators from the National Cancer Institute (NCI) and the Frederick National Laboratory for Cancer Research have been working collaboratively with experts in applied machine learning and computer science using the …

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Permanent link to this article: https://ncip.nci.nih.gov/blog/predictive-modeling-pre-clinical-drug-screening-improving-models-derived-observational-studies-using-machine-learning-simulation/

Jul 18

Population Level Pilot: Population Information Integration, Analysis, and Modeling for Precision Surveillance

Authors: Paul Fearn, Ph.D., MBA and Georgia Tourassi, Ph.D.

This is the fourth in a series of posts that discuss the principles underlying the three-year collaborative program “Joint Design of Advanced Computing Solutions for Cancer (JDACS4C).” Investigators from the National Cancer Institute (NCI) and the Frederick National Laboratory for Cancer Research have been working collaboratively with computational and data scientists affiliated with several national laboratories …

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Permanent link to this article: https://ncip.nci.nih.gov/blog/population-level-pilot-population-information-integration-analysis-modeling-precision-surveillance/

Jul 06

Introducing the Data Commons Framework

Author: Robert L. Grossman, Ph. D.

Robert L. Grossman, Ph.D. Frederick H. Rawson Professor Professor of  Medicine and Computer Science Jim and Karen Frank Director,  Center for Translational Data Science (CTDS) University of Chicago For this interview, the Center for Biomedical Informatics and Information Technology Communications Team interviewed Dr. Robert L. Grossman of the University of Chicago Center for Data Intensive …

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Permanent link to this article: https://ncip.nci.nih.gov/blog/introducing-data-commons-framework/

Jun 28

Modeling the Dynamics of Membrane-bound Mutant RAS to Accelerate Discovery of Novel Drug Targets

Authors: Dwight V. Nissley, Ph.D. and Frederick H. Streitz, Ph.D.

                    This is the third in a series of posts that discuss the principles underlying the three-year collaborative program “Joint Design of Advanced Computing Solutions for Cancer (JDACS4C).” Investigators from the National Cancer Institute (NCI) and the Frederick National Laboratory for Cancer Research have been working …

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Permanent link to this article: https://ncip.nci.nih.gov/blog/modeling-dynamics-membrane-bound-mutant-ras-accelerate-discovery-novel-drug-targets/